Wuzhou is located in eastern Guangxi bordering Guangdong province. It is at the confluence of the Gui River and the Xun River where they form the Xi River; 85% of all water in Guangxi flows through Wuzhou. The total area of Wuzhou is 12,588 km2.
Wuzhou is tropical/subtropical and monsoonal. The Tropic of Cancer bisects the city. Average annual temperature is 21.1°C and precipitation is 1500 mm. There are 1915 hours of sunlight annually.